Figure 2.
Development of local FK506 implant technology: (A) initial, unsuccessful iterations consisting of 15% drug-loaded devices measuring 10 mm × 10 mm each (10× film and 1× laminated versions), and (B) final, successful iteration consisting of 4 mm diameter circular implants loaded with 30 wt% tacrolimus and 1 wt% vitamin E (stabilizer to prevent degradation following sterilization and storage) totaling 3 cm2 (C) placed along the suture line and (D) final appearance on skin closure. Implants circled in yellow to aid visualization.