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. 2021 Jul;9(13):1070. doi: 10.21037/atm-21-313

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Proposed mechanism of action of local FK506 implant technology in averting rejection in vascularized composite allografts (VCA). (A) Previous studies from our laboratory suggest that skin cells within VCA dermis undergoes near complete turn-over and becomes infiltrated by recipient-origin leukocytes which likely results in rejection. (B) By delivering FK506 into the dermis directly through subcutaneous implantation, this infiltration of recipient-origin leukocytes may be delayed and/or negated completely, to mitigate the development of acute VCA rejection.