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Anti-VISTA mAb inhibited the inflammatory response and enhanced bacterial clearance. (a) MH5A suppressed the expression of TNF-α, IL-6, IL-10, and IFN-γ at 24 h post-CLP. (b) MH5A reduced the bacterial burden in peripheral blood and at the infection site. All presented data are a composite of three independent experiments (n = 6 − 8 in each group). ∗P < 0.05.
