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. 2021 Jul 22;11:628636. doi: 10.3389/fonc.2021.628636

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Copyright © 2021 Wu, Sheng, Qin, Cui, Yang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Establishment of ICC PDX models and application of drug screening. Part of the tissue of ICC after cholangiocarcinoma surgeries was transplanted into each group of mice correspondingly to cultivate cholangiocarcinoma. In the meanwhile, part of tissue was used for the analysis of targets for ICC using NGS technique to filter drugs with higher sensitivity and then administered on the treatment group. Through the analysis of drug efficacy against intrahepatic cholangiocarcinoma in the treatment group, the drugs with high sensitivity can be obtained and further acted on the human body.