Table 1.
CCA PDX models.
| Mouse strain | Tumor source | Planting pattern | Incision site | Implanted tumor volume | Target screen | Drug screen | References |
|---|---|---|---|---|---|---|---|
| NOD/Shi-SCID female mice | ICC | Subcutaneous transplantation | – | – | – | Ecteinascidin-743 | (40) |
| NOD/SCID/Il2rg null (NSG) mice | Metastatic lung nodule from IV ICC | Subcutaneous transplantation | Right flank | – | FGFR | BGJ398 | (41) |
| NOD/SCID mice | CCA | Subcutaneous transplantation | In the flank area in the middle of the thigh line | – | FGFR | BGJ398 | (42) |
| NOD/Shi-SCID mice | ICC | Subcutaneous transplantation | Subcutaneous | 4x4 mm | KRAS | – | (27) |
| NOD/SCID mice | ICC | Subcutaneous transplantation | – | – | SYK, LGALS1 | Trabectedin | (43) |
| CB17-/- SCID mice | ECC | Subcutaneous transplantation | Right flank | 5x5x5 mm | c-Myc | JQ1 | (24) |
| CB17SC-M-F scid−/− mice | ICC | Subcutaneous transplantation | The base of the tail | – | ADRM1 | RA190 | (44) |
| NOD/SCID mice | CCA | Subcutaneous transplantation | In the flank area in the middle of the thigh line | – | Hippo-YAP | Dasatinib | (45) |
| NOD/SCID mice | ICC | Subcutaneous transplantation | In the flank area in the middle of the thigh line | 1x1x1mm | FGFR | LY2874455 | (46) |
| NOD/SCID mice | CCA | Subcutaneous transplantation | In the flank area in the middle of the thigh line | – | SFK | SFK inhibitor | (47) |
| Balb/c Rag-2 -/-Jak3 -/- mice | CCA | Subcutaneous transplantation | – | – | CDK4/6-pRB | CDK4/6 inhibitor | (48) |
| NOD/SCID mice | CCA (stage IV) | Subcutaneous transplantation | Flanks | 3x3 mm | Bcl-xl-miR-876 | – | (49) |
| NOD/SCID mice | CCA | Subcutaneous transplantation | Bilateral subcutaneous pockets | 1–2 mm fragments | – | – | (50) |
| Balb/c nude Rag-2/Jak3-deficient (Nude RJ) mice | ICC, ECC | Subcutaneous transplantation | Flanks | 2-3 mm | – | – | (32) |
| BALB/c nude mice | CCA | Orthotopic transplantation | The liver at a depth of 3 mm | – | – | – | (29) |
| NOD/SCID/Il2rg-knockout (NSG) mice | ICC | Subcutaneous transplantation | Right flank | – | FGFR2-CCDC6 | Ponatinib | (51) |
| NOD/SCID mice | CCA | Subcutaneous transplantation | Flanks | 3x3x3 mm | VEGFR2 | Anlotinib | (52) |
| NOD/SCID mice | CCA | Subcutaneous transplantation | Subcutaneous | 3 mm3 | PTEN-proteasome | Bortezomib | (53) |
| NOD/SCID mice | CCA | Subcutaneous transplantation | Bilateral flanks | 1x1x1mm | – | – | (54) |
| NOD/SCID mice | CCA | Subcutaneous transplantation | Bilateral flanks | 1–2mm fragments | – | NUC1031 | (55) |
| NOD scid gamma (NSG) mice | CCA | Subcutaneous transplantation | Flanks | 3x3 mm | CDK2/5/9 | Dinaciclib | (56) |
| CD1 immunodeficient nude female mice | ICC | Subcutaneous transplantation | Subcutaneously in the flanks | – | Notch1 | LY3039478 | (57) |
| Female BALB/c (nu/nu) nude mice | ICC | Subcutaneous transplantation | Right flank | – | CDK7 | THZ1 | (58) |
| Male athymic nude mice | CCA | Subcutaneous transplantation | Flanks | 1–2 mm3 | PLVAP | Anti-PLVAP antibody | (59) |
| NOD/SCID mice | ICC | Subcutaneous transplantation | Subcutaneously in the flanks | 4x4 mm | – | – | (60) |
| Male NOD-Prkdcscid IL2rgtm1/Bcgen mice | ICC | Subcutaneous transplantation | Subcutaneous space of the upper left flank | – | TAN, TAM | – | (61) |
c-Myc,cellular-myelocytomatosis viral oncogene; CDK7, cyclin-dependent kinase 7; FGFR, Fibroblast Growth Factor Receptor; bcl-xl, B-cell lymphoma-xl; ADRM1, adhesion regulating molecule 1; CCDC6, coiled-coil domain containing 6; VEGFR2, Vascular Endothelial Growth Factor Receptor 2; PTEN, Phosphatase and tensin homologue deleted on chromosome 10; PLVAP, Recombinant Plasmalemma Vesicle Associated Protein; TAN, Tumor-associated neutrophil; TAM, Tumor-associated macrophage.