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. 2021 Jul 22;12:713960. doi: 10.3389/fimmu.2021.713960

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Copyright © 2021 Cai, Cui, Wang, You, Ji and Cao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo biodistribution analysis of BCCY-1. (A) In vivo imaging of mice and (B) ex vivo imaging of major organs at indicated hours after TAMRA-BCCY-1 treatment. Average radiant efficiency ([p/s/cm²/sr]/[μW/cm²]) was quantified at indicated time points. (C, D) The biodistribution of BCCY-1 in peripheral blood cells (lymphocytes, monocytes and granulocytes) was analyzed by flow cytometry at indicated hours. The percentage of TAMRA positive cells in the indicated cell population was quantified.