TABLE 4.

Role of miRNAs in regulation of gastric CSCs (ANTs, adjacent non-cancerous tissues).

microRNA	Samples	Cell lines	Target	Function	References
miR-196a-5p	95 pairs of GC and ANTs	Gastric cancer stem cell (GCSCs), SNU-5, BGC-823	Smad4, Sox2, Oct4, Nanog, CD44, N-cadherin, Vimentin, slug, Snail, E-cadherin	miR-196a-5p by targeting Smad4 could modulate GCSCs characteristics.	Pan et al., 2017
miR-26a	Mouse/Human/GEO database; 52 pairs of GC and ANTs	BGC823, MKN45, MKN28, SGC7901, 293T	HOXC9, E-cadherin, N-cadherin, Vimentin, MMP2, MMP7, Twist1, Zeb1, Snail1, SOX2, SOX4, Oct4, β-catenin	Dysregulation of miR-26a/HOXC9 could promote stem cell-like features and metastasis.	Peng et al., 2018
miR-7-5p	Mouse	BGC-823, SGC-7901, gastric cancer stem cells (GCSCs)	Smo, Hes1, c-myc, CD44, Sox2, Oct4, Nanog, Notch, Hedgehog	miR-7-5p via suppressing Hes1 and Smo could suppress GCSCs invasion.	Xin et al., 2020
miR-132	Mouse/Human; 20 pairs of GC and ANTs	Gastric cancer stem cell (GCSCs), MKN45, MKN28	SIRT1, CREB, ABCG2	miR-132 in Lgr5+ GCSCs-like cells via regulating SIRT1/CREB/ABCG2 pathway could contribute to cisplatin-resistance.	Zhang L. et al., 2017