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. 2021 Jul 22;12:696163. doi: 10.3389/fphys.2021.696163

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Copyright © 2021 Li, Xie, Zhou, Qu, Meng, Liu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Steatohepatitis was exacerbated in T2DM-M group compared with NGT-M group. (A) Representative liver HandE staining (magnification, ×200; scale bar: 50 μm) and Oil Red O staining (magnification, ×400; scale bar: 20 μm) (n = 13–17). (B) Hepatic histological analysis of HandE staining (NAS and lobular inflammation score) (n = 11–16). (C) Hepatic triglycerides and (free) cholesterol levels (n = 12–17). (D) Quantitative real-time RT-PCR analysis of TNF IL1B IL6 mRNA expressions in the liver from MAFLD patients (n = 13–16). The data are expressed as the mean ± SD, *P < 0.05, **P < 0.01, and ***P < 0.001.