Table 2. Participant Characteristics.
| Characteristic | Participants, No (%) | ||
|---|---|---|---|
| European ancestry, (n = 33 594) | African ancestry, (n = 3801) | Latinx ancestry, (n = 2196) | |
| Age, mean (SD), ya | 66.1 (17.7) | 59.6 (16.5) | 59.9 (19.4) |
| Breast cancer diagnosis | 3960 (11.8) | 274 (7.2) | 147 (6.7) |
| Age at breast cancer diagnosis, mean (SD), yb | 60.7 (13.0) | 58.8 (12.5) | 60.1 (13.0) |
| Estrogen receptor status, No. (% of cases) | |||
| Positive | 1052 (26.6) | 20 (7.3) | 22 (15.0) |
| Negative | 241 (6.1) | 15 (5.5) | 4 (2.7) |
| Missing | 2667 (67.3) | 239 (87.2) | 121 (82.3) |
| eMERGE network site | |||
| Columbia University Medical Center | 202 (0.6) | 73 (1.9) | 158 (7.2) |
| Geisinger | 1330 (4) | 4 (0.1) | 8 (0.4) |
| Partners Healthcare | 13 392 (39.9) | 927 (24.4) | 1093 (49.8) |
| Kaiser Permanente Washington Health Research Institute/University of Washington | 1646 (4.9) | 65 (1.7) | 55 (2.5) |
| Mayo Clinic | 3547 (10.6) | 10 (0.3) | 22 (1) |
| Marshfield Clinic Research Foundation | 2815 (8.4) | 8 (0.4) | |
| Mount Sinaic | 220 (0.7) | 2515 (66.2) | 742 (33.8) |
| Northwestern University | 1878 (5.6) | 207 (5.4) | 23 (1) |
| Vanderbilt University | 8564 (25.5) | 0 | 87 (4) |
Abbreviation: eMERGE, Electronic Medical Records and Genomics.
a
Age was calculated at the time of electronic phenotyping algorithm deployment.
b
Age at breast cancer diagnosis was defined as the age at the first breast cancer International Classification of Diseases–related code.
c
Mount Sinai only executed the phenotype algorithm for case-control definition; no estrogen receptor status data were extracted for this site.