Table 2.

General algorithm for dose interruptions and reductions according to the severity of apatinib-associated adverse events.

Grade of AE According to CTCAE	Treatment	Modification of Dose
Grade 1 or 2	Unchanged	No modification
Grade 3	Interruption until recovery to < grade 2	First episode: try to restart at full dose Second episode: reduce the dose until the AE has reduced in severity by 1 grade
Grade 3 to 4	As there is a risk of death, consider a permanent reduction or interruption

In some situations, grade 2 should lead to dose interruptions and reductions, e.g., wound complications and proteinuria. AE, adverse event; CTCAE, Common Terminology Criteria for Adverse Events.