Table 3. Diagnostic Accuracy and Odds Ratio of Each Melanoma-Specific Dermoscopic Structure and/or Pattern From Highest to Lowest Sensitivity.
| Structure | No. of studies (lesions) | % (95% CI) | Odds ratio (95% CI) | l2, % | |
|---|---|---|---|---|---|
| Sensitivity | Specificity | ||||
| Irregular pigmentation | 5 (1226) | 62.3 (31.2-85.8) | 78.6 (57.6-90.8) | 6.4 (2.0-20.5) | 87.9 |
| Blue-white veil | 17 (10 128) | 60.6 (46.7-72.9) | 79.7 (71.8-85.9) | 6.3 (3.7-10.7) | 89.0 |
| Atypical network | 19 (11 787) | 56.8 (43.6-69.2) | 71.8 (59.9-81.3) | 3.3 (2.4-4.5) | 83.8 |
| Multicomponent pattern | 9 (12 299) | 53.7 (40.4-66.4) | 82.4 (72.2-89.4) | 5.6 (2.4-13.0) | 96.6 |
| Atypical dots and/or globules | 17 (5497) | 49.7 (37.8-61.8) | 73.0 (61.8-81.9) | 2.7 (1.8-4.1) | 85.1 |
| Regression | 17 (10 542) | 48.1 (32.1-64.5) | 83.6 (69.7-91.9) | 4.6 (3.0-6.9) | 84.8 |
| Regression and peppering | 21 (11 739) | 44.9 (32.0-58.4) | 86.5 (77.3-92.4) | 4.7 (3.3-6.8) | 88.7 |
| Off-center blotch | 16 (12 850) | 42.1 (29.6-55.6) | 84.1 (74.6-90.5) | 3.8 (2.7-5.5) | 85.8 |
| Peripheral tan structureless area | 12 (8285) | 37.5 (22.3-55.7) | 76.1 (65.6-84.2) | 2.0 (1.3-3.0) | 50.4 |
| Peppering | 7 (7112) | 36.8 (19.1-58.9) | 93.4 (81.9-97.8) | 6.3 (2.4-16.1) | 91.6 |
| Negative network | 8 (7011) | 34.5 (30.5-38.7) | 70.8 (47.0-86.8) | 1.3 (0.7-2.4) | 79.2 |
| Scarlike areas | 8 (7328) | 31.3 (16.9-50.5) | 89.1 (83.7-92.9) | 4.4 (2.7-7.2) | 76.0 |
| Shiny white structures | 9 (9687) | 30.5 (15.8-50.7) | 93.6 (85.6-97.3) | 6.7 (2.5-17.9) | 95.2 |
| Linear irregular vessels | 5 (1806) | 23.2 (9.7-46.0) | 86.8 (74.3-93.7) | 2.1 (1.3-3.6) | 61.0 |
| Linear irregular vessels and polymorphous/atypical vessels | 18 (11 284) | 22.1 (14.6-32.1) | 81.6 (83.7-91.9) | 2.3 (1.7-3.1) | 35.8 |
| Polymorphous/atypical vessels | 17 (11 505) | 21.9 (13.3-33.8) | 89.0 (83.6-93.0) | 2.4 (1.7-3.4) | 80.6 |
| Streaks | 18 (11 035) | 21.1 (14.0-30.4) | 92.1 (88.4-94.7) | 3.1 (2.2-4.5) | 77.5 |
| Streaks and pseudopods | 18 (11 035) | 19.3 (13.9-26.2) | 83.8 (91.0-95.7) | 3.4 (2.6-4.6) | 38.1 |
| Pseudopods | 7 (6751) | 15.4 (8.8-25.6) | 97.3 (94.3-98.7) | 6.7 (2.7-16.1) | 70.3 |