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. 2021 Jul 22;12:688849. doi: 10.3389/fgene.2021.688849

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Copyright © 2021 Mi and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Univariable MR and multivariable MR analyses showed genetically proxied BMI and T2D were independent risk factors of carpal tunnel syndrome. Univariable MR was performed with IVW, weighted median, and MR-PRESSO methods. Multivariable MR was performed to assess the effect of T2D on CTS adjusted for BMI and the effect of BMI adjusted for T2D. *No outlier detected. IVW, inverse-variance-weighted; BMI, body mass index; T2D, type 2 diabetes; OR, odds ratio; CI, confidence interval; MR, Mendelian randomization.