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. 2021 Jul 22;12:688849. doi: 10.3389/fgene.2021.688849

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Copyright © 2021 Mi and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Univariable MR and multivariable MR analyses showing the associations of genetically proxied obesity-related factors with carpal tunnel syndrome. 1 SD increase of arm fat mass, arm fat-free mass, and waist circumference showed increased risk of carpal tunnel syndrome with outliers adjusted by MR-PRESSO. However, the causal associations were absent after adjustment for BMI. *No outlier detected. IVW, inverse-variance-weighted; BMI, body mass index; SD, standard deviation; OR, odds ratio; CI, confidence interval; MR, Mendelian randomization.