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. 2021 Jul 22;12:679897. doi: 10.3389/fimmu.2021.679897

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Copyright © 2021 Qu, Li, Xu, Zhao, Wu, Wang and Xie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Taxonomic analysis of microbiota in fecal samples at the phylum, class, order, family, and genus levels. (B) Ratio of Firmicutes to Bacteroidetes in the gut microbiota. (C) LDA scores for bacterial taxa significantly enriched in gut microbiota from each group (LDA score > 3). (D) Cladogram illustrating the results of LEfSe analysis. (E) All-against-all algorithm of LDA coupled with LEfSe. Ratios are expressed as the mean ± SEM, n = 6, analyzed using one-way ANOVA with Tukey post-hoc analysis. DSS (vs. DSS-Kae, *P < 0.05); Kae (vs. NC, ^a P < 0.05); ns, no significant difference. The significance of differences in taxonomic groups were assessed using the non-parametric factorial Kruskal-Wallis sum-rank test, n = 6. P < 0.05 was considered to indicate a significant difference between groups.