Table 1.
Characteristics of patients with advanced rNPC.
| Characteristics | Total = 120 | % |
|---|---|---|
| Gender | ||
| Male | 88 | 73.3 |
| Female | 32 | 26.7 |
| Age (years) | ||
| ≥50 | 65 | 54.2 |
| <50 | 55 | 18.3 |
| Smoking history | ||
| Yes | 30 | 25.0 |
| NO | 90 | 75.0 |
| Drinking history | ||
| Yes | 21 | 17.5 |
| No | 99 | 82.5 |
| Diabetes mellitus | ||
| Yes | 116 | 96.7 |
| No | 4 | 3.3 |
| Hypertension | ||
| Yes | 90 | 75.0 |
| No | 30 | 25.0 |
| BMI | ||
| 18.5–24.9 | 80 | 66.7 |
| <18.5 | 14 | 11.7 |
| >24.9 | 26 | 21.7 |
| Hemoglobin | ||
| ≥120 | 78 | 65.0 |
| <120 | 42 | 35.0 |
| NLR | ||
| ≥6 | 40 | 33.3 |
| <6 | 80 | 66.7 |
| Alkaline phosphatase | ||
| <50 | 6 | 5.0 |
| ≥50 | 114 | 95.0 |
| Period between recurrence and the last session of radiotherapy (year) | ||
| ≥3 | 68 | 56.7 |
| <3 | 52 | 43.3 |
| Preoperative combined chemotherapy | ||
| Yes | 99 | 82.5 |
| No | 21 | 17.5 |
| Histological subtype | ||
| WHO type II | 43 | 35.8 |
| WHO type III | 77 | 64.2 |
| rT stage | ||
| rT3 | 75 | 62.5 |
| rT4 | 45 | 37.5 |
| LNM | ||
| Yes | 28 | 23.3 |
| NO | 92 | 76.7 |
| Tumor necrosis | ||
| Yes | 64 | 53.3 |
| No | 56 | 46.7 |
| Tumor invasion of the ICA | ||
| No invasion | 79 | 65.8 |
| Invasion | 28 | 23.3 |
| Invasion, but ICA was embolized | 13 | 10.8 |
| The use of pedicled flap | ||
| Yes | 55 | 45.8 |
| No | 65 | 54.2 |
| Surgical margin | ||
| Negative margin | 85 | 70.8 |
| Positive margin | 35 | 29.2 |
| Postoperative radiotherapy | ||
| No | 112 | 93.3 |
| Yes | 8 | 6.7 |
| Postoperative chemotherapy | ||
| No | 94 | 78.3 |
| Yes | 26 | 21.7 |
| Postoperative PD-1 treatment | ||
| No | 111 | 92.5 |
| Yes | 9 | 7.5 |
| All patients with follow-up (mean months of survival) range) |
18 (2-81) | |
| Outcome | ||
| Remission | 39 | 32.5 |
| Deceased | 40 | 33.3 |
| Alive with disease | 41 | 34.2 |
rNPC, recurrent nasopharyngeal carcinoma; BMI, Body mass index; NLR, Neutrophil to lymphocyte ratio; LNM, lymph node metastasis; ICA, Internal carotid artery.