Table 3. Risk of Bias Evaluation for Each Included Study.

Source	Randomization process	Deviations from intended intervention	Missing outcome data	Measurement of the outcome	Selection of the reported result	Overall bias
NCT027990823,24	Low risk	Low risk	Low risk	Low risk	Some risk	Low risk
NCT0279906924,25	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Foley et al,26 2011	Low risk	Low risk	Low risk	Some risk	Low risk	Some risk
NCT0066873327	Some risk	Low risk	Low risk	Low risk	High risk	High risk
NCT0228168228	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Jorizzo et al,29 2007	Some risk	Low risk	High risk	Low risk	High risk	High risk
Krawtchenko et al,30 2007	Low risk	Some risk	Low risk	Low risk	Low risk	Some risk
Ostertag et al,31 2006	Low risk	Some risk	Low risk	High risk	High risk	High risk
NCT0084791232	Low risk	High risk	Low risk	Low risk	High risk	High risk
Stockfleth et al,33 2002	Low risk	High risk	Low risk	Low risk	High risk	High risk
NCT0098724635	Some risk	Low risk	Low risk	Low risk	High risk	High risk
NCT0030885436,37	Some risk	Low risk	Low risk	High risk	Low risk	Some risk
NCT0030886736,37	Some risk	Some risk	Low risk	Some risk	Low risk	Some risk
Zane et al,38 2014	Some risk	Some risk	Low risk	Low risk	Low risk	Some risk
Zane et al,39 2014	Some risk	Low risk	Low risk	Low risk	Low risk	Some risk