Table 1.
Description of follow-up time, including demographics and HIV sexual risk behaviours
|
Study visits with PrEP access |
180 days before and after PrEP access |
||||
|---|---|---|---|---|---|
| Before access | After access | Before access | After access | ||
| Number of women | 4582 | 2119 | 3675 | 2032 | |
| Person-years | 2860 | 556 | 919 | 481 | |
| Baseline VOICE risk score* | |||||
| 0–4 | 1633/4582 (36%) | 776/2119 (37%) | 1336/3675 (36%) | 751/2032 (37%) | |
| 5–9 | 2931/4582 (64%) | 1336/2119 (63%) | 2326/3675 (64%) | 1274/2032 (63%) | |
| Median age, years | 23 (20–26) | 23 (21–27) | 23 (20–27) | 23 (21–27) | |
| Number of visits | 10 278 | 2446 | 3774 | 2160 | |
| Study month | |||||
| 6 months | .. | .. | 51/3774 (14%) | .. | |
| 9 months | .. | .. | 797/3774 (21%) | 13/2160 (1%) | |
| 12 months | 4063/10 278 (40%) | 593/2446 (24%) | 735/3774 (19%) | 585/2160 (27%) | |
| 15 months | 3432/10 278 (33%) | 967/2446 (40%) | 777/3774 (21%) | 835/2160 (39%) | |
| 18 months | 2783/10 278 (27%) | 886/2446 (36%) | 955/3774 (25%) | 727/2160 (34%) | |
| Number of sexual partners | |||||
| 0 | 278/10 278 (3%) | 77/2446 (3%) | 86/3774 (2%) | 66/2160 (3%) | |
| 1 | 9366/10 278 (91%) | 2236/2446 (91%) | 3463/3774 (92%) | 1972/2160 (91%) | |
| 2 | 630/10 278 (6%) | 131/2446 (5%) | 225/3774 (6%) | 122/2160 (6%) | |
| Partner has other sexual partners | |||||
| No | 3336/10 278 (32%) | 812/2446 (33%) | 1216/3774 (32%) | 711/2160 (33%) | |
| Yes | 1003/10 278 (10%) | 212/2446 (9%) | 398/3774 (11%) | 186/2160 (9%) | |
| Do not know | 5935/10 278 (58%) | 1420/2446 (58%) | 2160/3774 (57%) | 1263/2160 (58%) | |
| Ever initiated PrEP at or before this visit | 270/10 278 (3%)† | 612/2446 (25%) | 17/3774 (0%) | 536/2160 (25%) | |
| Reported any unprotected sex† | 6667/10 278 (65%) | 1628/2446 (67%) | 2459/3774 (65%) | 1434/2160 (66%) | |
| New partner | 544/10 278 (5%) | 112/2446 (5%) | 196/3774 (5%) | 105/2160 (5%) | |
Data are n, n (%), or median (IQR). PrEP=pre-exposure prophylaxis.
VOICE risk score has been validated as a predictor of HIV incidence in African women and includes the following factors: age <25 years; unmarried or not living with partner; partner does not provide financial or material support; primary partner has other partners (yes or do not know); alcohol use in the past 3 months; or having a curable sexually transmitted infection. VOICE risk score was measured at baseline and is a characteristic of the woman at enrollment. All other covariates were assessed at every visit.
For 227 (88%) of these women, their PrEP initiation date was between ECHO quarterly visits and after initiation of on-site PrEP access. These intervals with partial PrEP access are included in the before access data.