Table 1.
Estimated parameters (fixed effect) for SARS-CoV-2 infection in nose and throat.
| Parameter name | Symbol (unit) | Nose | Throat |
|---|---|---|---|
| Parameters in the model | |||
| Maximum rate constant for viral replication | γ (d−1) | 18.2 | 2.89a |
| Rate constant for virus infection | β ([copies/ml]−1 d−1) | 1.79 × 10-6 | 6.70 × 10-6 |
| Death rate of infected cells | δ (d−1) | 1.14 | |
| Efficacy of blocking virus production by RDV | ε (−) | 0.618 | |
| Viral load at virus inoculation | V(0) (copies/ml) | 2.86 × 103 | |
| Quantities derived from the parameters | |||
| Within-host basic reproduction number | R0 (=γ/δ) | 16.0 | 2.54a |
| Malthusian parameter | M (=γ − δ) | 17.1 | 1.75a |
a
Statistically different from nose (the Wald test).