Skip to main content
. 2021 Aug 5;19(8):e06770. doi: 10.2903/j.efsa.2021.6770
ADI Acceptable Daily Intake
ADME Absorption, Distribution, Metabolism, Excretion
AMKL Acute Megakaryoblastic Leukaemia
ARfD Acute Reference Dose
BMD Benchmark Dose
BMDL Lower confidence Limit of the Benchmark Dose
BMR Benchmark Response
CDKs Cyclin‐dependent kinases
cGAMP or cyclic GMP–AMP Cyclic guanosine monophosphate–adenosine monophosphate
cGAS Cyclic guanosine monophosphate–adenosine monophosphate synthase
CREST Calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly and telangiectasia
CSGMT Collaborative Study Group of the Micronucleus Test
CytB Cytochalasin B
FISH Fluorescence in situ hybridisation
GIT Gastrointestinal Tract
GIT MN assay Gastrointestinal Tract Micronucleus assay
HBGV Health‐Based Guidance Value
IWGT International Workshop on Genotoxicity Test
IWGTP International Workshop on Genotoxicity Test Procedures
JEMS Japanese Environmental Mutagen Society
MMS Mammalian Mutagenicity Study
MN Micronucleus/micronuclei
MOE Margin of Exposure
NOAEL No Observed Adverse Effect Level
NOEL No Observed Effect Level
OECD Organisation for Economic Co‐operation and Development
OECD TG 471 Bacteria reverse mutation text guideline (AMES test)
OECD TG 474 The mammalian erythrocyte micronucleus test guideline
OECD TG 487 In vitro mammalian cell micronucleus test guideline
OECD TG 488 Transgenic rodent assay
OECD TG 489 In vivo mammalian alkaline comet assay
SC Scientific Committee
TDI Tolerable Daily Intake
ToR Terms of Reference
TTC Threshold of Toxicological Concern
UF Uncertainty Factor
WHO World Health Organization