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Cyclic peptides derived from apelin-13.301 (A) Sequence of apelin-13. (B) In REMD simulations, cyclo-(QRPRLS) and cyclo-(QRPRLSH) adopted a β turn at residues RPRL and showed stronger inhibition in experiment. (C) In contrast, cyclo-(QRPRLSHK) and cyclo-(QRPRLSHKG) adopted a β turn at residues RLSH and showed weaker inhibition in experiment.
