Table 1.

Gene ontology (GO) functional enrichment analysis for up- and downregulated genes after treatment with EGCG.

No.	GO accession	Upregulated	NES	FDR	P
1	GO:0006082	Organic acid metabolic process	2.45	0	0
2	GO:0019752	Carboxylic acid metabolic process	2.36	0	0
3	GO:0032787	Monocarboxylic acid metabolic process	2.24	0	0
4	GO:0006631	Fatty acid metabolic process	2.15	0	0
5	GO:2001289	Lipid metabolic process	2.08	0	0.001
6	GO:0008654	Phospholipid biosynthetic process	1.98	0	0.002
7	GO:0044255	Cellular lipid metabolic process	1.97	0	0.003
8	GO:0016042	Lipid catabolic process	1.85	0.002	0.019
9	GO:0006732	Coenzyme metabolic process	1.85	0	0.018
10	GO:0044242	Cellular lipid catabolic process	1.84	0.005	0.017
11	GO:0046467	Membrane lipid biosynthetic process	1.83	0.004	0.018
12	GO:0008610	Lipid biosynthetic process	1.77	0	0.033
13	GO:0015980	Energy derivation by oxidation of organic compounds	1.77	0.005	0.032
14	GO:0044270	Nitrogen compound catabolic process	1.75	0.007	0.033
15	GO:0008202	Steroid metabolic process	1.73	0.002	0.038
16	GO:0006519	Amino acid and derivative metabolic process	1.72	0.002	0.043
17	GO:0006807	Nitrogen compound metabolic process	1.71	0	0.042
18	GO:0009056	Catabolic process	1.71	0	0.04
19	GO:0044248	Cellular catabolic process	1.65	0	0.065
20	GO:0006520	Amino acid metabolic process	1.64	0.015	0.067
No.	GO accession	Downregulated	NES	FDR	P
1	GO:0007599	Hemostasis	−1.91	0	0.063
2	GO:0030155	Regulation of cell adhesion	−1.87	0	0.056
3	GO:0007596	Blood coagulation	−1.83	0.004	0.073
4	GO:0009611	Response to wounding	−1.83	0	0.058
5	GO:0050817	Coagulation	−1.82	0.002	0.052
6	GO:0045597	Positive regulation of cell differentiation	−1.81	0.004	0.051
7	GO:0050878	Regulation of body fluid levels	−1.81	0.002	0.045
8	GO:0009605	Response to external stimulus	−1.73	0	0.1
9	GO:0051707	Response to other organism	−1.72	0	0.1
10	GO:0006952	Defense response	−1.71	0	0.102
11	GO:0042060	Wound healing	−1.7	0.002	0.103
12	GO:0008544	Epidermis development	−1.68	0.003	0.118
13	GO:0009617	Response to bacterium	−1.68	0.015	0.111
14	GO:0009607	Response to biotic stimulus	−1.67	0.005	0.117
15	GO:0045595	Regulation of cell differentiation	−1.67	0.002	0.11
16	GO:0051259	Protein oligomerization	−1.66	0.012	0.113
17	GO:0007398	Ectoderm development	−1.65	0.012	0.12
18	GO:0009888	Tissue development	−1.61	0.003	0.157
19	GO:0016337	Cell–cell adhesion	−1.61	0.009	0.156
20	GO:0050863	Regulation of t cell activation	−1.59	0.017	0.169

Note: Gene sets with FDR < 0.25 are shown (top 20 when there are >20 gene sets with FDR < 0.25). Abbreviation: NES, normalized enrichment score.