TABLE 1.

Characteristics of WDEIA patients, diagnosed by oral food challenge: sex, age, BMI, atopic dermatitis, total IgE (KU/L), sIgE (KU/L) against wheat flour, rye flour, gluten, gliadins, ω5‐gliadin, lipid‐transfer protein, dermatophagoides pteronyssinus, timothy grass, birch pollen allergen, cofactor, symptoms, severity according to Messmer and Ring and involved organ systems

Patients	Sex	Age	BMI	AD	Total IgE	sIgE									Cofactor	Symptoms	Severity
						WF	RF	G	Glia	ω5	Tri a 14	DP	TG	Bet v1
1	F	45	19	‐	203.0	0.72	0.66	0.65	0.29	8.12	<0.10	0.28	0.37	<0.10	Exercise, NSAID, stress, mental strain	i, f, u, g, gi, v	II (skin, gut)
2	M	39	21	‐	97.3	0.32	0.73	0.80	1.10	3.47	<0.10	0.34	<0.10	<0.10	Exercise	i, f, u, g	I (skin)
3	M	42	28	RCA, A	105.0	0.83	0.82	0.73	0.87	3.97	<0.10	<0.10	0.82	<0.10	Exercise, stress, mental strain	i, u, r, un, d	III (skin, respiratory tract, CVS)
4	M	60	32	RCA	50.0	0.47	1.19	2.08	1.53	4.98	<0.10	<0.10	<0.10	0.32	Exercise, stress	i, u, un	III (skin, CVS)
5	M	48	29	‐	95.0	0.32	0.26	0.28	0.13	1.52	<0.10	0.22	<0.10	<0.10	Exercise	i, f, un	III (skin, CVS)
6	M	54	24	RCA, A	319.0	1.44	3.40	5.89	4.67	10.70	<0.10	0.17	0.60	<0.10	Exercise, NSAID, stress, cold, heat, mental strain	i, u, h	II (skin, CVS)
7	F	47	37	‐	95.3	0.14	0.16	0.22	<0.10	0.32	<0.10	0.25	<0.10	<0.10	Exercise, NSAID, alcohol	u, r, un	III (skin, respiratory tract, CVS)
8	M	55	27	RCA	368.0	2.70	2.98	7.38	5.10	11.40	<0.10	0.9	2.49	5.15	Exercise, alcohol, cold, heat	i, f, u, un	III (skin, CVS)
9	F	52	23	‐	172.0	0.55	1.51	2.41	2.25	5.04	<0.10	<0.10	3.55	0.75	Exercise, AA, alcohol	i, f, u, r, g, un, h	III (skin, respiratory tract, CVS)
10	F	54	29	‐	90.3	0.47	1.14	1.26	0.64	4.09	<0.10	<0.10	0.17	<0.10	AA, stress, cold, mental strain	i, f, u	I (skin)
11	M	56	29	RCA, AE	2193.0	5.95	7.04	11.70	11.00	30.20	<0.10	15.60	>100	<0.10	AA	i, f, u, r, g, v	II (skin, gut)
12	F	26	23	‐	82.6	0.21	0.45	<0.10	<0.10	<0.10	<0.10	0.38	1.46	0.20	Exercise	i, f, u, g	I (skin)

Abbreviations: A, asthma; AA, acetylsalicylic acid; AD, atopic disease; AE, atopic eczema; Bet v1, birch pollen allergen; BMI, body mass index; CVS, cardiovascular system; DP, dermatophagoides pteronyssinus; f, flush; g, globus sensation; G, gluten; gi, gastrointestinal complaints; Glia, gliadins; h, hypotension; i, itching; NSAID, non‐steroidal anti‐inflammatory drugs; OAS, oral allergy syndrome; r, respiratory distress; RCA, allergic rhinoconjuctivitis; RF, rye flour; sIgE, specific immunoglobulins; TG, timothy grass; Tri a 14, lipid‐transfer protein; u, urticaria; un, unconsciousness; v, vomiting; WF, wheat flour; ω5, ω5‐gliadin.