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. 2021 Aug 5;12:437. doi: 10.1186/s13287-021-02503-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Autophagy participated in the BK-regulated apoptosis induced by H₂O₂ in hCPCs. A–B Representative image and quantitative analysis of TUNEL staining in hCPCs induced by H₂O₂ or rapamycin and treatment with BK or 3-MA. C Quantitative analysis of Annexin V flow cytometry assay in hCPCs induced by H₂O₂ or rapamycin and treatment with BK or 3-MA. D Apoptosis-related protein expression, including Bax, Bcl-2, cleaved caspase 3, induced with H₂O₂ or rapamycin, and treatment with BK or 3-MA. E Autophagy-related protein expression, including LC3II/I, Beclin 1, and P62, induced with H₂O₂ or rapamycin and treatment with BK or 3-MA. (Data are shown as mean ± SEM, n = 5, *P < 0.05, **P < 0.01 VS. control; #P < 0.05, ##P < 0.01 VS. H₂O_2; &P < 0.05, &&P < 0.01 VS. Rapa)