Table 2. H–D Exchange Reaction of Indoles and Carbazole.
a
D content was calculated based on the 1H NMR spectra of the isolated product.
b
Isolated yield.
c
Isolated yield of CD3 ester.
d
98% ee.
e
The reaction was conducted in a sealed tube.
f
>99% ee.
g
Reactions were performed in a 0.05 M solution.
h
D content was calculated based on 1H NMR spectroscopy after N-methylation.
i
After isolating deuterated carbazole (70% average D incorporation), the H–D exchange reaction of this product was performed again.