Table 1.
Patient data
| Cognitive status | ||||
|---|---|---|---|---|
| Overall | Normal | Impaired* | p | |
| Demographics | ||||
| Average age at testing (range) | 83.2 (52.9–105.1) | 81.0 (52.9–102.4) | 88.3 (69.8–105.1) | < 0.0001 |
| Total (Male / Female) | 174 (82 / 92) | 124 (63 / 61) | 50 (19 / 31) | 0.126*** |
| Age at last visit (%) | ||||
| < 60 | 7 (4.0) | 7 (5.6) | 0 (0.0) | |
| 60–69 | 15 (8.6) | 14 (11.3) | 1 (1.7) | |
| 70–79 | 33 (19.0) | 30 (24.2) | 3 (5.2) | |
| 80–89 | 76 (43.7) | 45 (36.3) | 31 (53.4) | |
| 90 + | 51 (29.3) | 28 (22.6) | 23 (39.7) | |
| Education, at least some college (%) | 32 (18.4) | 15 (78.9) | 17 (77.3) | 0.89 |
| History of psychiatric illness (%) | 45 (25.9) | 29 (31.9) | 17 (45.9) | 0.13 |
| Neuropathological data | ||||
| Argyrophilic grains | 32 (18.4) | 12 (9.7) | 10 (20.0) | 0.06 |
| Lewy body pathology (incidental) | 16 (9.2) | 11 (8.9) | 5 (10.0) | 0.82 |
| Cerebrovascular disease** | 27 (15.5) | 6 (4.8) | 21 (42.0) | < 0.0001 |
| Infarcts (vascular brain injury) | 37 (21.3) | 24 (19.4) | 13 (26.0) | 0.33 |
| Hippocampus ARTAG positive (%) | 43 (24.7) | 25 (21.6) | 18 (38.3) | 0.03 |
| Genetic data | ||||
| Presence of ≥ 1 APOE ε4 allele | 22 (12.6) | 16 (12.9) | 6 (11.3) | 0.77 |
| Presence of ≥ 1 APOE ε2 allele | 46 (26.4) | 27 (21.8) | 19 (35.8) | 0.06 |
| Presence of ≥ 1 MAPT H2 | 59 (33.9) | 42 (36.2) | 17 (36.2) | 1 |
* Mild cognitive impairment or dementia, ** excluding cerebral amyloid angiopathy, ***Male sex, significant values in bold (Chi squared test)