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. 2021 Aug 4;22:592. doi: 10.1186/s12864-021-07876-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — A. Aberrant upstream and downstream interactors of YAP1. Upstream interactors include one significantly downregulated miRNAs (miR-375) and interaction with TSC1 and PTEN. Downstream, YAP1 interacts directly or indirectly with several genes the RNA expression of which has been found significantly upregulated. B. Aberrant upstream and downstream interactors of GRB2 are shown. Upstream interactors include an indirect interaction with PTEN (through PTK2). Downstream, GRB2 interacts with several genes like SHC1, K-RAS, JUN and CDK4. C. miRNAs upstream of HDAC4 significantly downregulated in HCC tumors compared to the control tissue. D. miRNAs upstream of SIRT1 significantly upregulated in HCC tumors compared to the control tissue. The expression counts have been normalized with respect to library sizes and have been transformed for variance stabilization. Shown are normalized expression counts of the miRNAs upstream of Sirt1. The expression counts have been normalized in the same way as in C. Blue color indicates downregulated or genomic deletion, grey color indicates not regulated and red color indicates upregulation