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. 2021 Aug 5;115:55–61. doi: 10.1016/j.niox.2021.08.001

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© 2021 The Author

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 2 — Lifestyle factors boost NO bioavailability to prevent COVID-19 progression

Inhibitory effects of lifestyle factors on COVID-19 progression are transmitted via NO-mediated signaling and finally integrated to cGMP-dependent and -independent pathways.

NO: nitric oxide, SNAP: S-nitroso-N-acetylpenicillamine, SNP: sodium nitroprusside, NOS: NO synthase, Hb: hemoglobin, Mb: myoglobin, XOR: xanthine oxidoreductase,Fe–NO: nitrosyl iron, N₂O₃: dinitrogen trioxide, SNO: S-nitrosothiol, cyclic cGMP: cyclic guanosine-3′, 5′-monophosphate, COVID-19: coronavirus disease.