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In vivo antitumor efficacy of free ODN1826, CCMV-ODN1826, and control VLPs in a murine model of melanoma. A) Treatment schedule. B) Growth curves of melanoma tumors, showing mean tumor volumes ± standard deviations (n = 8–10). Statistical significance was determined by two-way ANOVA (***p < 0.001). C) Tumor growth kinetics for each treatment group. D) Survival curves. Statistical significance was determined using the long-rank (Mantel-Cox) test (***p < 0.001).
