Table 3.
Unadjusted Associations between RNFL Thickness in the Various RNFL Sectors and Demographic and Ocular Characteristics
| Characteristic | Age, y | Sexa | Ethnicity: East or Southeast Asian vs. Europeanb | Ethnicity: Other Ethnicity vs. Europeanb | Axial Length (mm) | IOP (mm Hg) | Smoking |
|---|---|---|---|---|---|---|---|
| G | −1.29 (−2.42, −0.17) P = 0.02 | −1.21 (−2.34, −0.18) P = 0.02 | −5.27 (−8.43, −2.11) P = 0.001 | −0.39 (−3.01, 2.23) P = 0.77 | −2.69 (−3.16, −2.22) P < 0.001 | −0.05 (−0.14, 0.03) P = 0.22 | −0.35 (−2.11, 1.42) P = 0.70 |
| T | −1.32 (−2.53, −0.11) P = 0.03 | −1.74 (−2.84, −0.64) P = 0.002 | 2.52 (0.16, 4.88) P = 0.04 | −1.50 (−3.46, 0.46) P = 0.13 | 1.74 (1.15, 2.33) P < 0.001 | 0.14 (−0.01, 0.28) P = 0.06 | −3.80 (−5.79, −1.92) P < 0.001 |
| TS | −1.41 (−3.43, 0.60) P = 0.17 | −1.65 (−3.49, 0.20) P = 0.08 | 0.70 (−3.24, 4.64) P = 0.73 | −3.18 (−6.46, 0.09) P = 0.06 | −2.30 (−3.28, −1.33) P < 0.001 | 0.06 (−0.17, 0.30) P = 0.59 | −0.93 (−4.05, 2.19) P = 0.56 |
| NS | −2.35 (−4.69, −0.02) P = 0.05 | −1.49 (−3.63, 0.65) P = 0.17 | 3.57 (−1.00, 8.15) P = 0.13 | 0.34 (−3.46, 4.14) P = 0.86 | −3.93 (−5.05, −2.80) P < 0.001 | −0.40 (−0.68, −0.12) P = 0.005 | 2.57 (−1.07, 6.22) P = 0.17 |
| N | −0.52 (−2.14, 1.09) P = 0.53 | 0.54 (−0.94, 2.02) P = 0.47 | −5.27 (−8.43, −2.11) P = 0.001 | −0.39 (−3.01, 2.23) P = 0.77 | −4.05 (−4.81, −3.29) P < 0.001 | −0.08 (−0.27, 0.10) P = 0.10 | 1.48 (−1.05, 4.01) P = 0.25 |
| NI | −1.37 (−4.07, 1.33) P = 0.32 | −0.40 (−2.87, 2.07) P = 0.75 | −2.28 (−7.56, 3.00) P = 0.40 | 1.05 (−3.34, 5.43) P = 0.64 | −7.13 (−8.38, −5.88) P < 0.001 | −0.44 (−0.73, −0.15) P = 0.003 | 3.45 (−0.77, 7.66) P = 0.11 |
| TI | −1.57 (−3.69, 0.56) P = 0.15 | −4.10 (−6.03, −2.17) P < 0.001 | 0.53 (−3.62, 4.68) P = 0.80 | −3.84 (−7.29, −0.39) P = 0.03 | −2.60 (−3.63, −1.58) P < 0.001 | −0.17 (−0.40, 0.07) P = 0.17 | −2.95 (−6.26, 0.36) P = 0.08 |
Linear mixed models were used to analyze associations. A random intercepts term was included for participants to account for correlation between eyes. Values represent the average change in RNFL thickness (µm) in each sector (row headings) for each 1-unit increase in the explanatory variables (column headings). Values in brackets show the 95% confidence intervals for the estimate, and P values are shown after the 95% confidence intervals. Bold values are significant with the Bonferroni correction (P < 0.007). G, global; N, nasal; NI, inferonasal; NS, superonasal; T, temporal; TI, inferotemporal; TS, superotemporal.
Female sex is the reference group.
European ethnicity is the reference group.