Table I.
Demographic and clinical features and serum sIgE levels of the study population (n = 100)
| Demographic, clinical, and immunologic features | PA (n = 50) | PS (n = 40) | NA (n = 10) | P value |
|---|---|---|---|---|
| Age (y) | 8.31 (1.68-17.91) | 5.93 (0.52-15.81) | 5.96 (0.77-12.58) | .003 |
| Sex: male | 36 (72) | 25 (62.5) | 8 (80) | .371 |
| Atopic eczema | 17 (34) | 18 (45) | 2 (20) | .287 |
| Asthma/wheezing | 29 (58) | 13 (33) | 1 (10) | .016 |
| Allergic rhinitis | 33 (66) | 14 (35) | 1 (10) | .003 |
| Other food allergy | 38 (76) | 33 (83) | 2 (20) | .453 |
| SPT wheal size to peanut (mm) | 9 (1-34)† | 3 (0-12)† | 0 (0-0) | <.0001 |
| tIgE (kUA/L) | 297.5 (4-3,550) | 469 (7-10,714) | 29.5 (6-397) | .5757 |
| sIgE to peanut (kUA/L) | 12 (0.2-568) | 2.41 (0.04-128) | 0.01 (0-0.9) | .0019 |
| sIgE to Ara h 1 (kUA/L) | 0.80 (0-199) | 0.11 (0-88.3) | 0 (0-0.01) | .0838 |
| sIgE to Ara h 2 (kUA/L) | 2.54 (0.01-278) | 0.07 (0-82.3) | 0.04 (0.01-0.07) | <.0001 |
| sIgE to Ara h 3 (kUA/L) | 0.36 (0-89.6) | 0.06 (0-7.28) | 0.01 (0-0.04) | .0456 |
| sIgE to Ara h 6 (kUA/L) | 3.835 (0-155) | 0.03 (0-86) | 0 (0-0.29) | <.0001 |
| sIgE to Ara h 8 (kUA/L) | 0.09 (0-185) | 0.04 (0-88.6) | 0 (0-0.02) | .4022 |
| sIgE to Ara h 9 (kUA/L) | 0.02 (0-871) | 0.05 (0-43.9) | 0.01 (0-0.02) | .0834 |
| Peanut SA (%) | 5.03 (0.06-81.71) | 0.82 (0.02-7.68) | 0.03 (0-0.18) | <.0001 |
| Ara h 1 SA (%) | 0.37 (0-24.34) | 0.03 (0-2.12) | 0 (0-0.04) | .0038 |
| Ara h 2 SA (%) | 2.48 (0.01-55.26) | 0.012 (0-1.86) | 0.09 (0.01-0.83) | <.0001 |
| Ara h 3 SA (%) | 0.14 (0-9.98) | 0.019 (0-0.90) | 0.01 (0-0.67) | .0002 |
| Ara h 6 SA (%) | 1.91 (0-25.63) | 0.01 (0-1.06) | 0 (0-0.41) | <.0001 |
| Ara h 8 SA (%) | 0.05 (0-11.90) | 0.01 (0-7.77) | 0 (0-0.04) | .2862 |
| Ara h 9 SA (%) | 0.01 (0-1.5) | 0.01 (0-4.72) | 0.01 (0-0.17) | .3529 |
| PD | 0.97 (0-1.41) | 0 (0-1.35) | 0 (0-0) | <.0001 |
| WD | 1.985 (0-3.39) | 1.82 (0-3.1) | 0 (0-1.32) | .4945 |
| Avidity (%inhibition)‡ | 41.07 (15.94-72.5) | 28.63 (7.43-50) | — | <.0001 |
| MAT to peanut (%CD63+ LAD2 cells) | 24.6 (0-79.9) | 4.18 (0-31.65) | 1.09 (0-3.9) | <.0001 |
| BAT to peanut† (%CD63+ basophils)∗ | 37.55 (1.75-90.79) | 1.57 (0-16.6) | 0.36 (0-0.99) | <.0001 |
Values are expressed as n (%) or median (range). P value refers to the comparison between PA and PS patients.
∗
BAT = PA (n = 23), PS (n = 54), NA (n = 7).
†
SPT = PA (n = 49), PS (n = 38), PA + PS (n = 87).
‡
For avidity analyses, n = 60, with PA (n = 36) and PS (n = 24).