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Possible structure and cellular constituents of TG. TG is an organized aggregate of immune cells. In classic TG, there is a necrotic area in the center, surrounded by a large number of immune cells such as T cells, B cells and macrophages. MSCs have been found to exist in TG and may be involved in the formation and development of granuloma. However, the location of MSCs in TG and their relationship with immune cells are still unclear.
