TABLE 1.

Binding affinities of antipsychotics for human receptors (K_i , nmol/L)

Receptors	Brexpiprazole	Aripiprazole	Olanzapine	Quetiapine	Risperidone	Haloperidol
D2	0.30	0.34	20	180	2.2	1.4
D3	1.1	0.8	50	940	9.6	2.5
5‐HT1A	0.12	1.7	2100	230	210	3600
5‐HT2A	0.47	3.4	3.3	220	0.29	120
5‐HT2C	34	96	10	1400	10	4700
5‐HT7	3.7	39	250	1800	3.0	1100
α1	3.8 a	52 a	54	15	1.4	4.7
H1	19	61	2.8	8.7	19	440
M1	>1000	6800	4.7	100	2800	1600

^a α_1A receptor, the K_i values are quoted from Maeda et al, ¹⁰ Citrome et al, ³⁴ and Miyamoto et al. ³⁵