Table 3.
Summary of odd ratios (OR) and 95% CIs of NLRP3 rs35829419 polymorphism and autoimmune diseases (AIDs) susceptibility for various comparisons.
| Stratification | N | AA vs. CC | AC vs. CC | AA/AC vs. CC | AA vs. AC/CC | A vs. C | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CIs) | Ph | OR (95%CIs) | Ph | OR (95%CIs) | Ph | OR (95%CIs) | Ph | OR (95%CIs) | Ph | ||
| Total | 14 | 0.45 (0.22, 0.93) | 0.948 | 1.00 (0.77, 1.30) | 0.043 | 0.93 (0.71, 1.20) | 0.036 | 0.45 (0.22, 0.92) | 0.948 | 0.89 (0.69, 1.14) | 0.038 |
| Ethnicity | |||||||||||
| European | 7 | 0.47 (0.17, 1.29) | 0.882 | 0.86 (0.70, 1.04) | 0.520 | 0.84 (0.69, 1.02) | 0.625 | 0.48 (0.17, 1.30) | 0.877 | 0.83 (0.69, 0.99) | 0.673 |
| Latin American | 4 | 0.20 (0.02, 1.71) | 0.960 | 1.45 (0.51, 4.14) | 0.008 | 1.32 (0.44, 4.00) | 0.004 | 0.21 (0.02, 1.73) | 0.963 | 1.21 (0.39, 3.72) | 0.002 |
| Arab | 3 | 0.62 (0.18, 2.09) | 0.449 | 1.23 (0.77, 1.98) | 0.242 | 1.09 (0.66, 1.78) | 0.134 | 0.60 (0.18, 2.03) | 0.449 | 1.06 (0.67, 1.69) | 0.175 |
| Disease type | |||||||||||
| PsA | 1 | 0.54 (0.09, 3.25) | NA | 0.98 (0.71, 1.35) | NA | 0.96 (0.70, 1.32) | NA | 0.54 (0.09, 3.26) | NA | 0.95 (0.70, 1.28) | NA |
| T1D | 2 | 1.88 (0.12, 30.62) | NA | 0.77 (0.33, 1.78) | 0.675 | 0.82 (0.37, 1.84) | 0.764 | 1.95 (0.12, 31.74) | NA | 0.88 (0.41, 1.88) | 0.856 |
| CD | 3 | 0.64 (0.03, 15.84) | NA | 1.63 (0.39, 6.82) | < 0.001 | 1.59 (0.39, 6.55) | <0.001 | 0.62 (0.02, 15.42) | NA | 1.52 (0.40, 5.78) | <0.001 |
| MS | 1 | 0.35 (0.06, 1.95) | NA | 1.92 (0.82, 4.51) | NA | 1.40 (0.66, 2.94) | NA | 0.32 (0.06, 1.81) | NA | 1.09 (0.57, 2.09) | NA |
| RA | 5 | 0.27 (0.08, 0.97) | 0.962 | 0.84 (0.65, 1.10) | 0.921 | 0.76 (0.58, 1.00) | 0.827 | 0.28 (0.08, 1.00) | 0.957 | 0.74 (0.57, 0.96) | 0.813 |
| SLE | 1 | 0.22 (0.01, 4.54) | NA | 0.88 (0.36, 2.20) | NA | 0.75 (0.31, 1.81) | NA | 0.22 (0.01, 4.58) | NA | 0.65 (0.28, 1.51) | NA |
| MG | 1 | 3.18 (0.15, 67.59) | NA | 1.90 (0.49, 7.35) | NA | 2.33 (0.62, 8.73) | NA | 3.03 (0.14, 64.33) | NA | 2.68 (0.75, 9.62) | NA |
N, number of studies involved; Ph, p-value of Q-test for heterogeneity test; OR, odds ratios; NA, not available; PsA, psoriatic arthritis; T1D, type 1 diabetes; CD, celiac disease; MS, multiple sclerosis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; MG, myasthenia gravis.