Table 4.
Summary of OR and 95% CIs of NLRP3 rs10754558 polymorphism and AIDs susceptibility for various comparisons.
| Stratification | N | GG vs. CC | GC vs. CC | GG/GC vs. CC | GG vs. GC/CC | G vs. C | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CIs) | Ph | OR (95% CIs) | Ph | OR (95% CIs) | Ph | OR (95% CIs) | Ph | OR (95% CIs) | Ph | ||
| Total | 8 | 0.63 (0.51, 0.77) | 0.345 | 0.78 (0.66, 0.91) | 0.082 | 0.73 (0.63, 0.84) | 0.096 | 0.73 (0.62, 0.88) | 0.370 | 0.78 (0.71, 0.87) | 0.159 |
| Ethnicity | |||||||||||
| European | 1 | 0.90 (0.59, 1.39) | NA | 1.06 (0.75, 1.50) | NA | 1.01 (0.73, 1.41) | NA | 0.87 (0.60, 1.26) | NA | 0.96 (0.78, 1.19) | NA |
| Latin American | 4 | 0.45 (0.33, 0.62) | 0.941 | 0.64 (0.51, 0.81) | 0.854 | 0.58 (0.47, 0.72) | 0.945 | 0.58 (0.44, 0.78) | 0.817 | 0.65 (0.56, 0.76) | 0.935 |
| Arab | 2 | 0.71 (0.38, 1.32) | 0.844 | 0.50 (0.30, 0.82) | 0.550 | 0.55 (0.34, 0.89) | 0.713 | 1.15 (0.70, 1.91) | 0.531 | 0.84 (0.63, 1.12) | 0.905 |
| Asian | 1 | 0.73 (0.50, 1.08) | NA | 1.01 (0.74, 1.39) | NA | 0.92 (0.68, 1.23) | NA | 0.72 (0.51, 1.02) | NA | 0.86 (0.71, 1.05) | NA |
| Disease type | |||||||||||
| T1D | 1 | 0.45 (0.25, 0.81) | NA | 0.69 (0.44, 1.07) | NA | 0.61 (0.41, 0.91) | NA | 0.55 (0.32, 0.93) | NA | 0.64 (0.48, 0.86) | NA |
| CD | 2 | 0.76 (0.52, 1.12) | 0.090 | 0.99 (0.73, 1.34) | 0.373 | 0.91(0.68, 1.21) | 0.175 | 0.77 (0.55, 1.08) | 0.141 | 0.88 (0.73, 1.07) | 0.08 |
| MS | 1 | 0.74 (0.34, 1.61) | NA | 0.44 (0.24, 0.84) | NA | 0.51 (0.28, 0.94) | NA | 1.30 (0.69, 2.43) | NA | 0.85 (0.60, 1.22) | NA |
| RA | 1 | 0.45 (0.27, 0.76) | NA | 0.57 (0.39, 0.84) | NA | 0.53 (0.37, 0.76) | NA | 0.61 (0.37, 0.98) | NA | 0.63 (0.49, 0.81) | NA |
| SLE | 2 | 0.67 (0.48, 0.94) | 0.403 | 0.89 (0.68, 1.17) | 0.129 | 0.82 (0.64, 1.05) | 0.151 | 0.72 (0.53, 0.96) | 0.898 | 0.82 (0.69, 0.97) | 0.331 |
| MG | 1 | 0.65 (0.23, 1.84) | NA | 0.78 (0.66, 0.91) | NA | 0.62 (0.28, 1.38) | NA | 0.93 (0.40, 2.16) | NA | 0.82 (0.51, 1.32) | NA |
N, number of studies involved; Ph, p-value of Q-test for heterogeneity test; OR, odds ratios; NA, not available; T1D, type 1 diabetes; CD, celiac disease; MS, multiple sclerosis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; MG, myasthenia gravis.