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. 2021 Jun 2;78(2):308–318. doi: 10.1097/FJC.0000000000001069

FIGURE 2.

FIGURE 2.

CUR-PDT inhibited the phenotypic transformation, migration, and foaming of ox-LDL–treated VSMCs. The expression of proteins related to phenotype transformation (α-SMA, SM22-α, and OPN) was detected by western blotting after different treatments for 6 hours. The migration of VSMCs was detected by transwell assay. The accumulation of lipid droplets in VSMCs was measured by Oil Red O staining after CUR-PDT. A, Effect of CUR-PDT on the expression of proteins related to phenotype transformation in ox-LDL–treated MOVAS cells; (B) effect of CUR-PDT on the expression of proteins related to phenotype transformation in ox-LDL–treated A7r5 cells; (C) effect of CUR-PDT on migration of ox-LDL–treated MOVAS cells; (D) effect of CUR-PDT on migration of ox-LDL–treated A7r5 cells; (E) effect of CUR-PDT on accumulation of lipid droplets in ox-LDL–treated MOVAS cells; and (F) effect of CUR-PDT on accumulation of lipid droplets in ox-LDL–treated A7r5 cells. n = 3 (3 independent experiments). Data are expressed as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.