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. 2021 Jun 2;78(2):308–318. doi: 10.1097/FJC.0000000000001069

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Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 4. — 3-MA reversed the effect of CUR-PDT on the phenotype transformation in VSMCs treated with ox-LDL. The expression of proteins related to autophagy (Beclin-1, p62, and LC3B) and proteins related to phenotype transformation (α-SMA, SM22-α, and OPN) were detected by western blotting in VSMCs after different treatments for 6 hours. A, Effect of 3-MA on the expression of proteins related to autophagy and proteins related to phenotype transformation in ox-LDL–treated MOVAS cells and (B) effect of 3-MA on the expression of proteins related to autophagy and proteins related to phenotype transformation in ox-LDL–treated A7r5 cells. n = 3 (3 independent experiments). Data are expressed as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.