Table 6.
Correlations Between DNMT mRNAs and GABAergic, BDNF and Glucocorticoid mRNAs.
mRNA | DNMT1(or) (L) | DNMT1-cus | DNMT3A | ||||||
---|---|---|---|---|---|---|---|---|---|
All Subjects | CSZ | NPC | All Subjects | CSZ | NPC | All Subjects | CSZ | NPC | |
GAD1(L) | +0.043 | −0.058 | +0.097 | +0.177 | +0.117 | −0.074 | +0.023 | −0.010 | −0.268 |
GAD67(Ln) | +0.282* | +0.070 | +0.492** | +0.075 | +0.052 | +0.022 | +0.201 | +0.120 | +0.079 |
BDNF (bc) (L) | +0.053 | +0.27O | −0.210 | +0.156 | +0.089 | +0.009 | +0.514***B | +0.600***B | +0.344 |
BDNFIX (L) | +0.352**B | +0.373 | +0.296 | +0.266*B | +0.256 | +0.253 | +0.544***B | +0.589***B | +0.502**B |
NR3C1 (bc) (SR) | +0.106 | +0.319 | +0.106 | +0.537***B | +.0.465**B | +0.504**B | +0.459***B | +0.394*B | +0.437*B |
NR3C1-cus | +0.359**B | +0.451* | +0.220 | +0.560***B | +0.543***B | +0.561***B | +0.541***B | +0.518**B | 0.490**B |
Each number is Pearson (r) correlation between indicated mRNAs measured in lymphocytes. N’s All subjects 52–71, Schizophrenics 25–38, NPC controls 27–33. Transformations: (L)=log10, (Ln)= Log2, SR= square root. Significance:
P<.05,
P≤.01,
P≤.001.
= survived protected significance level with BH procedure (α=.05) using the 6 mRNA comparisons. Nonparametric correlations (rho) on non-transformed values were in the same range.