Table 7.
DNMT1 and GAD67 mRNA in Frontal Cortex in Brains of Subjects with Schizophrenia and Controls
| mRNA | Schizophrenia (CSZ) | Controls (NPC) | Analysis Of Variance or T-Test |
|---|---|---|---|
| DNMT1 Layer 1 | FD= 27.453, df=1,41, P=<.001 FS= 0. 308, df=1,41, P=0.582 FD*S= 0.169, df=1,41, P=0.683 |
||
| All Subjects | 233.11± 43.74 (n=19) | 164.77± 34.70 (n=26) | |
| Males | 237.67±49.22 (n=12) | 165.26 ± 39.160(n=19) | T= 4.540, df=29, P <0.001 |
| Females | 225.29 ± 34.41(n=7) | 163.43 ± 20.354(n=7) | T=−4.094, df=12 P=0.001 |
| DNMT1 Layer 2 | FD= 24.455, df=1,41, P<.001 FS= .207, df=1,41, P=0.652 FD*S= 563, df=1,41, P=0.458 |
||
| All Subjects | 469.89± 67.59 (n=19) | 363.85 ± 68.609 (n=26) | |
| Males | 459.92±50.61 (n=12) | 365.63 ±74.19 (n=19) | T=3.860, df=29, P=0. .001 |
| Females | 487.00 ± 92.04* (n=7) | 359.00± 55.34 (n=7) | T=3.153, df=12, P=0.008 |
| DNMT1 Layer 5 | FD= 0.007, df=1,41, P 0.936 FS= 0.674, df=1,41, P=0.417 FD*S=0.707, df=1,41, P=0.405 |
||
| All Subjects | 189.37± 38.24 (n=19) | 185.08 ±46.23 (n=26) | |
| Males | 198.00 ± 32.91 (n=12) | 185.00± 50.55 (n=19) | T= 0.789, df=29, P=0.437 |
| Females | 174.57 ±44.68 (n=7) | 185.29± 35.16 (n=7) | T= 0.499 df=12, P=0. 627 |
| GAD67 Layer 1 | FD= 12.093, df=1,41, P=.001 FS= 2.577, df=1,41, P=0.116 FD *S= 0.193, df=1,41, P=0 663 |
||
| All Subjects | 160.79 ± 30.70 (n=19) | 201.65 ± 35.37 (n=26) | |
| Males | 165.42± 34.37 (n=12) | 207.58 ± 35.97 (n=19) | T= 3.233, df=29, P=.003 |
| Females | 152.86 ± 23.38 (n=7) | 185.57 ± 30.33 (n=7) | T=2.260, df=12, P=0. 043 |
| GAD67 Layer 2 | FD= 24.452, df=1,41, P<.001 FS= 0. 146, df=1,41, P=0.704 FD *S= 0.981, df=1,41, P=0.328 |
||
| All Subjects | 355.15± 62.61 (n=19) | 439.88 ± 52.28 (n=26) | |
| Males | 359.33± 78.26 (n=12) | 433.00± 48.64 (n=19) | T=3.245, df=29, P=.003 |
| Females | 348.00±± 20.88 (n=7) | 458.57 ± 61.11(n=7) | TU=4.530, df=7.382, P=0.002 |
Values are Mean± S.D. DNMT1 and GAD67 mRNA positive neurons/mm3×102
FD=F diagnosis effect; FS=F sex effect; FD*S=F interaction-diagnosis
*
sex effect. T= 2-sample t-test. TU= two sample
t-test with unequal variances.