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| Ligand | k off (s−1) | k on a (106 M−1 s−1) | K d b (10−6 M) |
|---|---|---|---|
| L2 | 28 ± 9 | 1.6 ± 0.5 | 18.2 ± 0.2 |
| L3 | 8 ± 1 | 2.4 ± 0.4 | 3.3 ± 0.1 |
| pL4 | 13 ± 1 | 5.2 ± 0.8 | 2.5 ± 0.3 |
| mL4 | 8 ± 1 | 3.9 ± 0.7 | 2.0 ± 0.3 |
| oL4 | 32 ± 5 | 4.4 ± 1.1 | 7.2 ± 1.3 |
k on is determined from Kd and koff.
Dissociation constants determined by ITC under sample conditions near-identical to those used for CPMG dispersion experiments.
