TABLE 4.
Effect of BSTN1 on FBG, PPBG, F-Ins and HOMA-IR in treated and untreated rats.
Parameters | Normal control | HFD control | BSTN1-1.25 mg | BSTN1-2.5 mg | BSTN1-5 mg | ORL-5 mg |
---|---|---|---|---|---|---|
FBG (mg/dl) | 86.12 ± 4.6 | 159.6 ± 8.0# | 133.0 ± 6.1* | 115.1 ± 9.2** | 91.2 ± 7.1*** | 97.3 ± 6.9*** |
PPBG (mg/dl) | 99.6 ± 5.0 | 211.1 ± 9.4# | 174.6 ± 3.7* | 141.5 ± 8.7** | 100.3 ± 5.7*** | 104.7 ± 3.9*** |
F-Ins (µIU/ml) | 14.57 ± 1.8 | 18.07 ± 1.3# | 15.33 ± 2.1* | 15.09 ± 2.0** | 14.72 ± 1.7*** | 14.94 ± 1.1*** |
HOMA-IR | 3.1 | 7.1# | 5.0* | 4.3** | 3.3*** | 3.6*** |
# p < 0.001 indicates significant difference between HFD control and normal control. *, ** and *** indicate significant difference between HFD control and treated groups at p < 0.05, p < 0.01, and p < 0.001, respectively. FBG, fasting blood glucose; PPBG, post-prandial blood glucose; F-Ins, fasting insulin; HOMA-IR, homeostasis model assessment index for insulin resistance.