Fig. 4. Ultra-structural studies of untreated S. cerevisiae, treated with 2a or with fluconazole tested at 5 μM and 30 °C incubation temperature. The pictures showed starting with a 6 h incubation formation of vesicles, ascribable as apoptotic bodies and loss of membrane integrity. After longer incubation times a shrinking effect as well as nuclear blebbing could be also noted.
