Fig. 5. pIC50 values (−log IC50) for all compounds against the mitochondrial complex II and III pathway (SQR) from rat liver mitochondria, and rAOX's from C. albicans and C. auris. Control denotes control compounds for each specific pathway, with antimycin A for SQR and ascofuranone for the AOX pathways. Data was collected in a 96-well plate format, following cytochrome c reduction (ΔA550) for the SQR pathway, and NADH oxidation (ΔA340) for the AOX pathway. All data are a mean average of 3 biological replicates ±SEM.
