Enzyme Inhibition studies of different cytochrome P450 enzyme by the compound 2a and its parent drug (IC50 in μM). Standard deviation shown in upper script.
Compound | CYP2C9 | CYP2C8 | CYP2C19 | CYP3A4 | CYP1A | CYP2D6 |
---|---|---|---|---|---|---|
Fluconazole | 13.9 ± 1.63 | 97.2 ± 27.9 | 3.02 ± 0.34 | 25.8 ± 2.45 | >100 | >100 |
2a | 3.33 ± 0.71 | 0.64 ± 0.09 | <0.4 | 0.4 ± 0.06 | 10.4 ± 0.41 | 2.71 ± 0.12 |