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. 2021 Jul 8;2(4):1263–1273. doi: 10.1039/d1cb00123j

Enzyme Inhibition studies of different cytochrome P450 enzyme by the compound 2a and its parent drug (IC50 in μM). Standard deviation shown in upper script.

Compound CYP2C9 CYP2C8 CYP2C19 CYP3A4 CYP1A CYP2D6
Fluconazole 13.9 ± 1.63 97.2 ± 27.9 3.02 ± 0.34 25.8 ± 2.45 >100 >100
2a 3.33 ± 0.71 0.64 ± 0.09 <0.4 0.4 ± 0.06 10.4 ± 0.41 2.71 ± 0.12