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. 2020 Dec 8;2(1):94–150. doi: 10.1039/d0cb00136h

Half-life evaluations of NP-ODN against nuclease S1, CSPDE and SVPDE161.

ODN (5′ → 3′)a t 1/2 RNase-H activation
Nuclease S1 CSPDE SVPDE
d[(T)11T] 7 min 22 min 14 min ✓
d[TNP(T)5TNPT] 20.7 h 26 h 9 h ✗
d[(TNP)3(T)5-(TNP)3T] 7 min 12 d 8.5 h ✓
a

NP refers to the P-NH2 phosphoramidate internucleoside linkage.