Half-life evaluations of MP-ODN against CSPDE and SVPDE exonucleases, and DNase I and DNase II endonucleases175.
| ODN (5′ → 3′)a | t 1/2 | |||
|---|---|---|---|---|
| CSPDE | SVPDE | DNase I | DNase II (h) | |
| d(TGACTTAGCTGCAT) | 30 min | 12 min | 10 min | 10 |
| d(TGACMPTTAGCMPTGCMPAT) | >100 h | >100 h | 60 min | 20 |
| d(TGMPACMPTTMPAGMPCTMPGCMPAT) | >100 h | >100 h | >100 h | >50 |
MP refers to a methylphosphonate internucleoside linkage.