. 2020 Dec 8;2(1):94–150. doi: 10.1039/d0cb00136h

Thermal denaturation studies (T_m values) of chimeric ODN with combination of LNA and MP linkages with complementary DNA or RNA and their half-lives towards induced SVPDE hydrolysis (once the modified nucleoside was reached)¹⁷⁷.

ODN (5′ → 3′)^a	T _m with DNA (°C)	T _m with RNA (°C)	t _1/2 (min)
d(GTGATATGC)	29	27	<2
d(GT^LGAT^LAT^LGC)	44	53	<5
d(GTG_MPATA_MPTGC)	27	22	30
d(GT^LG_MPAT^LA_MPT^LGC)	39	47	>60

L and MP refer to LNA residues and methylphosphonate internucleoside linkages respectively.

Thermal denaturation studies (Tm values) of chimeric ODN with combination of LNA and MP linkages with complementary DNA or RNA and their half-lives towards induced SVPDE hydrolysis (once the modified nucleoside was reached)177.