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. 2020 Dec 8;2(1):94–150. doi: 10.1039/d0cb00136h

Thermal denaturation studies (Tm values) of MPS-ODN with complementary RNA and their half-life evaluations against SVPDE287.

ODN (5′ → 3′)a T m with RNA (°C) t 1/2 (s)
d(ACACCCAATT-CTGAAAATGG) 51.2 44
d(ACACCCAATT-CTGAAAATMPSGMPSG) 47.8 210
d(ACACCCAATT-CTGAAAAMPSTMPSGMPSG) 48 264
d(ACACCCAATT-CTGAAAMPSAMPSTMPSGMPSG) 47.1 401
a

MPS refers to the methylphosphonothioate internucleoside linkage.