. 2020 Dec 8;2(1):94–150. doi: 10.1039/d0cb00136h

Thermal denaturation studies (T_m values) of different ODN with complementary DNA or RNA and their half-life evaluations against SVPDE¹³⁶.

ODN (5′ → 3′)^a	T _m with DNA^b (°C)	T _m with RNA^b (°C)	t _1/2 (min)
d(GCGTTTTTTGCT)	50	45	—
d(GCGTTT_5′SPT^LTTGCT)	52	53	—
d(GCGTT_5′SPT^L_5′SPT^L_5′SPT^LTGCT)	43	50	—
d(GCGT_5′SPT^LT_5′SPT^LT_5′SPT^LGCT)	53	60	—
d(TTTTTTTTT_5′SPT^L)	—	—	>40
d(TTTTTTTTT_5′SP^MeC^L)	—	—	>40
d(TTTTTTTTTT)	—	—	8
d(TTTTTTTTT^MeC)	—	—	>40
d(TTTTTTTTT_PST)	—	—	>40

PS and 5′SP refer to the phosphorothioate and 5′-SP internucleoside linkages respectively. L refers to LNA residues.

ODN not tested.

Thermal denaturation studies (Tm values) of different ODN with complementary DNA or RNA and their half-life evaluations against SVPDE136.