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| ODN (5′ → 3′)a | t 1/2 | |
|---|---|---|
| FCS | Human serum | |
| d(TCCAGTGATTTTTTTCTCCAT) | <5 min | ∼3 h |
| d(TPSCPSCPSAPSGPSTPSGPSAPSTPSTPS-TPSTPSTPSTPSTPSCPSTPSCPSCPSAPST) | ∼4 h | >7 d |
| d(TCCAGTGATTTTTTTCTCCNPANPT) | ∼4 h | >7 d |
| d(TNPCNPCAGTGATTTTTTTCTCCAT) | <5 min | ∼3 h |
| d(TCCAGTGATTTTTTTCTCCA3′-3′POT | ∼4 h | >7 d |
| d(TCCAGTGATTTTTTTCTCCA3′-3′NPT | ∼4 h | >7 d |
PS and NP refer to the phosphorothioate and MEA phosphoramidate internucleoside linkages respectively.
