Table 3.
Univariate and multivariate analyses of the risk factors of OS and DFS in patients with gastric cancer.
| OS (n = 102) | DFS (n = 86) | |||||||
| Variables | Univariate analysis | Multivariable analysis | Univariate analysis | Multivariable analysis | ||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Gender (male vs female) | 1.072 (0.580–1.9982) | .824 | 0.875 (0.389–1.967) | .747 | ||||
| Age | 0.996 (0.973–1.020) | .730 | 0.981 (0.954–1.008) | .167 | ||||
| ASA | 0.932 (0.603–1.439) | .749 | 0.808 (0.477–1.369) | .428 | ||||
| Operative time (min) | 1.006 (1.001–1.012) | .031 | 1.000 (0.995–1.006) | .897 | 1.003 (0.996–1.011) | .386 | ||
| Estimated blood loss (ml) | 1.001 (1.000–1.002) | .206 | 1.001 (1.000–1.002) | .274 | ||||
| Tumor location | .284 | .233 | ||||||
| Upper 1/3 | Reference | Reference | ||||||
| Middle 1/3 | 0.512 (0.186–1.410) | .195 | 0.226 (0.051–1.005) | .051 | ||||
| Lower 1/3 | 0.806 (0.439–1.480) | .487 | 0.671 (0.344–1.306) | .240 | ||||
| More than 1/3 | 1.530 (0.592–3.952) | .380 | 0.585 (0.132–2.597) | .481 | ||||
| Histopathology | .381 | .065 | ||||||
| Papillary | Reference | Reference | ||||||
| Tubular | 1.691 (0.712–4.015) | .234 | 4.746 (1.130–19.931) | .033 | ||||
| Mucinous | 1.533 (0.432–5.433) | .508 | 2.697 (0.380–19.153) | .321 | ||||
| Signet-ring cell | 2.324 (0.890–6.063) | .085 | 7.084 (1.565–32.064) | .011 | ||||
| Tumor differentiation (poorly vs moderately/ well differentiated) | 1.928 (1.108–3.353) | .020 | 1.373 (0.736–2.561) | .319 | 1.732 (0.924–3.245) | .087 | ||
| Vascular invasion | 1.233 (1.560–2.715) | .603 | 1.366 (0.525–3.398) | .544 | ||||
| Neural invasion | 0.994 (0.472–2.092) | .987 | 1.174 (0.522–2.639) | .698 | ||||
| Primary tumor size | 4.269 (2.210–8.247) | <.001 | 1.500 (0.656–3.426) | .336 | 4.263 (2.035–8.928) | <.001 | 1.942 (0.753–5.010) | .170 |
| (> 5 vs ≤5 cm) | ||||||||
| Borrmann type | 3.049 (1.732–5.365) | <.001 | 1.643 (0.865–3.122) | .130 | 2.068 (1.111–3.850) | .022 | 0.804 (0.493–1.313) | .384 |
| (III/IV vs I/II) | ||||||||
| Pathological T stage | 2.566 (1.838–3.581) | <.001 | 1.714 (1.064–2.759) | .027 | 2.954 (1.963–4.445) | <.001 | 2.071 (1.220–3.517) | .007 |
| Pathological N stage | 1.780 (1.429–2.217) | <.001 | 1.001 (0.755–1.326) | .996 | 1.615 (1.265–2.062) | <.001 | 1.109 (0.837–1.468) | .472 |
| Pathological M stage | 18.561 (8.986–38.336) | <.001 | 8.935 (3.796–21.031) | <.001 | ||||
| VN expression | 4.909 (2.674–9.011) | <.001 | 2.758 (1.392–5.462) | .004 | 7.223 (3.438–15.174) | <.001 | 5.370 (2.459–11.725) | <.001 |